Archive for the ‘Medical Research’ Category

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Literature Review Finds No Indication that Soy Decreases Testosterone Levels

ST LOUIS, July 20 /PRNewswire/ — A new study published by the American Society for Reproductive Medicine finds that soyfoods and soy isoflavone supplements have no significant effect on male reproductive hormone levels in men. The literature review indicates that soy does not decrease testosterone levels.

Led by Jill M. Hamilton-Reeves, PhD, RD, of St. Catherine’s University, St. Paul, Minnesota, researchers assessed the effects of soy protein and soy isoflavones on measurements of male reproductive hormones. Findings, just published online in Fertility and Sterility, a publication of the American Society for Reproductive Medicine, demonstrate no significant effect of soy protein or soy isoflavone intake on circulating levels of testosterone, sex hormone-binding globulin or free testosterone in men.

The comprehensive meta-analysis examined the existing scientific literature including all clinical studies examining soy’s effect on male reproductive hormones published before July 1, 2008. Fifteen placebo-controlled treatment groups with baseline and ending measures were analyzed. Thirty-two reports involving 36 treatment groups were also assessed in simpler statistical models. Studies published after July 1, 2008, which were not included in the meta-analysis, support the conclusions of the meta-analysis.

Reproductive endocrinologist William R. Phipps, MD, of the University of Rochester Medical Center, a co-author of the analysis stated, “As a high-quality source of protein that is relatively low in saturated fat, soy can be an important part of a heart-healthy diet and may contribute to a decreased risk of coronary heart disease.” He noted that some men have been reluctant to consume soyfoods due to concerns about estrogen-like effects of soy isoflavones, often referred to as phytoestrogens. But according to Phipps, “it is important for the public to understand that there is no clinical evidence to support these ideas. After conducting a comprehensive review of the existing literature, we found no indication that soy significantly alters male sex hormone levels.”

Men can benefit from soyfood consumption as a means to meet daily protein requirements and at the same time possibly also reducing their risk of heart disease.

Citing the research study, Lisa Kelly, MPH, RD, of the United Soybean Board, added, “Soy is often praised for the positive role it can play in the diets of women. But, years of clinical research have shown that men stand to benefit from soy, too. I encourage men to incorporate soyfoods into a balanced and varied diet and talk to their healthcare provider about their own unique nutritional needs.”

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Biostar Pharmaceuticals, Inc. (BSPM.OB) received local approval for three TCM products, which it expects to begin selling later this month. The company projects a total of $3.5 million in revenues from the three products in 2009, and $7.4 million in 2010. Biostar anticipates they will produce net income of $1 million this year and $2 million in 2010.

Biostar has built a rural cooperative medicine supply network to distribute these products alongside its existing drugs. The network currently consists of about 1,320 sales outlets in rural areas, which Biostar plans to expand into 10,000 sales outlets in two years.

The three new products are:

  • Yizi Capsules – a TCM aimed at infertility in women and believed to aid in healthy fetal development during pregnancy. It is one of only a few nutritional supplement products marketed for infertility

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Researchers at the Northeast England Stem Cell Institute have come up with a way to create human sperm from embryonic stem cells. The journal Stem Cells and Development last week published research led by Karim Nayernia, of Newcastle University.

The research isn’t intended to make men obsolete. On the contrary, the science behind it could someday give couples struggling with fertility hope for starting a family.

What Nayernia and his team of scientists did was come up with a way to turn embryonic stem cells with male chromosomes into reproductive cells.

They then divided the cells, which in turn produced sperm.

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Women wanting to get pregnant should find themselves an ugly man, new research suggests.

Scientists have found attractive males produce less sperm during sex.

Researchers think good-looking males are biologically geared to hold back their sperm in each encounter to increase their chance of impregnating more females.

But unattractive males know they are not going to bed so many females — so when they do get lucky they give it all they’ve got.

The findings from the University of Oxford and University College London are backed up by studies of chickens and fish, but researchers think they could well apply to humans too.

“Human attractiveness is complicated and influenced by a number of factors including cultural preferences,” said UCL researcher Sam Tazzyman. “Nonetheless, ejaculate size and sperm quality are likely to have been molded by similar forces, like attractiveness and the number of sexual partners, that are important in other species.”

Reporting the findings on the university’s Web site, Tazzyman said, “The more attractive a male is, the more females will be willing to mate with him, reducing the value of each mating to him. This means it is optimal for him to contribute fewer sperm per mating.”

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Women with cystic fibrosis can have fertility treatment to help them have babies without any long-term adverse effects on either themselves or their children, according to new research presented at the 25th annual meeting of the European Society of Human Reproduction and Embryology in Amsterdam today.

Until relatively recently, cystic fibrosis (CF) was a death sentence and most people with the disease died by the time they reached their teenage years. Now, this is no longer the case, and, thanks to better treatment of the condition, people live far longer and want to start their own families. But women with CF face a problem in addition to the effects of on their health: CF itself can make them infertile.

In the first, long-running study to investigate and evaluate systematically the use of assisted reproductive technology (ART) in a group of with CF, researchers based at the Hôpital Cochin Saint Vincent de Paul in Paris (France) looked at 24 women between 1998 and 2008. After assessing their health, three women were discouraged from undergoing for medical reasons and six are still being assessed. However, the remaining 15 women all received fertility treatment.

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Sportsmen who carry out high levels of cycle training could be damaging their chance of fatherhood, researchers reported on Monday.

The research team looked at triathletes — athletes who run, swim and cycle — to further a probe into a long-suspected link between male infertility and long-distance biking.

They looked at semen provided by 15 healthy Spanish triathletes whose training routines were known in detail.

The more time the triathletes spent in the saddle, the worse their sperm fared, said the research team, which Diana Vaamonde led at the University of Cordoba Medical School in Spain.

“While all triathletes had less than 10 percent of normal-looking sperm, the men with less than 4 percent — at which percentage they generally would be considered to have significant fertility problems — were systematically” 180 miles a week on their bicycles, Vaamonde said.

No such link was seen for running and swimming.

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Washington, June 30: French doctors have unveiled a new technique for transplanting the ovaries of women who have lost their fertility as a result of cancer treatment.

The technique, described by Pascal Piver of the Limoges University Hospital in central-western France, has helped a young woman who had been menopausal for two years to give birth to a healthy baby girl.

Using a two-step process, they restored fertility to the woman after she had undergone chemotherapy treatment for sickle-cell anaemia, a disease in which red blood cells become dangerously misshaped.

Ovarian transplants, pioneered in 2004, entail removing an ovary from a woman before she undergoes cancer therapy. The organ is frozen and then thawed and returned to the patient after her treatment.

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WEBWIRE – Tuesday, June 30, 2009

Amsterdam, The Netherlands: Daily sex (or ejaculating daily) for seven days improves men’s sperm quality by reducing the amount of DNA damage, according to an Australian study presented today (Tuesday) to the 25th annual meeting of the European Society of Human Reproduction and Embryology in Amsterdam.

Until now there has been no evidence-based consensus amongst fertility specialists as to whether or not men should refrain from sex for a few days before attempting to conceive with their partner, either spontaneously or via assisted reproduction.

Dr David Greening, an obstetrician and gynaecologist with sub specialist training in reproductive endocrinology and infertility at Sydney IVF, Wollongong, Australia, said: “All that we knew was that intercourse on the day of ovulation offered the highest chance of pregnancy, but we did not know what was the best advice for the period leading up to ovulation or egg retrieval for IVF.

“I thought that frequent ejaculation might be a physiological mechanism to improve sperm DNA damage, while maintaining semen levels within the normal, fertile range”

To investigate this hypothesis, Dr Greening studied 118 men who had higher than normal sperm DNA damage as indicated by a DNA Fragmentation Index (DFI). Men who had a more than 15% of their sperm (DFI more than 15%) damaged were eligible for the trial. At Sydney IVF, sperm DNA damage is defined as less than 15% DFI for excellent quality sperm, 15-24% DFI for good, 25-29% DFI for fair and more than 29% DFI for poor quality; but other laboratories can have slightly different ranges.

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Yale researchers may have solved a fundamental medical mystery: how bisphenol A (BPA), a ubiquitous plastics component, changes genetic chemistry and impairs fertility.

The Yale team’s findings, previewed earlier this month to the Endocrine Society, a 14,000-member scientific and medical professional organization devoted to hormone system research and treatment, have intensified scientists’ concern that exposure BPA, a synthetic estrogen that disrupts the endocrine system, may have grave consequences for human reproduction.

In an interview, study co-author Hugh S. Taylor, M.D., professor and chief of the reproductive endocrinology section at Yale University School of Medicine, said his team injected pregnant mice with BPA for just one week. After those mice, and a control group, gave birth, the scientists found that the genetic chemistry of female offspring exposed to BPA in the womb had been irrevocably altered.

A particular gene known as HOXA10, responsible for normal uterine development and fertility in both mice and humans, had been stripped of numerous so-called “methyl groups,” each composed of a single hydrogen atom and three carbon atoms.

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CHICAGO, June 18 (UPI) — Fatherhood might be far from the minds of most young men, but their behavior when young can contribute to later male infertility, a U.S. researcher said.

Dr. Suzanne Kavic, a reproductive specialist at the Loyola University Chicago Stritch School of Medicine, said heat generated by hot tubs, excessive laptop use, or using boxers over briefs can impact sperm production, making it difficult to conceive down the road.

Other leading causes of male infertility include: enlarged varicose veins in the scrotum, genital injuries or defects, certain sexually transmitted infections, an infection or inflammation of the prostate, immune and hormonal disorders and erectile dysfunction.

Medications for depression

, blood pressure and certain heart conditions may lower libido or cause impotence,” Kavic said in a statement. “Men should talk with their physicians to see if medication is necessary or if they can switch to another with fewer side effects.”

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